• On the other hand a major advantage of

  2018-11-08

  

  On the other hand, a major advantage of this alternative double-reporter genetic model is to provide a clear-cut qualitative answer as to whether new CMs are formed after injury and if so, whether these new CMs originated predominantly from pre-existing CMs or from another cell population. If no new

• br Materials and methods br

  2018-11-08

  

  Materials and methods Resource table Resource details This line was derived from a 62-year-old female with familial hypertrophic cardiomyopathy (HCM). HCM is a genetic heart disease with a prevalence of up to 1 in 200 people and is characterised by unexplained hypertrophy of the left ventricl

• Apart from genetic fate mapping strategies both Ki labeling

  2018-11-08

  

  Apart from genetic fate-mapping strategies, both Ki-67 labeling and birth dating with thymidine analogs or 14C might be confounded by polyploidization and multinucleation. Analyses should therefore be performed at the nuclear level. Thus, additional measures are required to establish turnover in car

• br Materials and methods br

  2018-11-08

  

  Materials and methods Results Discussion Here we establish a molecular signature for unmodified SCDSs that were initiated by individual multipotent SSCs in comparison with SCDSs that were initiated by Special Health Care Needs that were not multipotent, based upon their differentiation capa

• PDGs possess a specific architecture and

  2018-11-08

  

  PDGs possess a specific architecture and molecular signature that make them distinct from the pancreatic epithelium, instead resembling gastric stem cell glands. PDGs were also found to express and up-regulate TFF genes during injury. In the stomach TFF1 is normally found predominantly in the epithe

• Micro array data has been submitted to Gene Expression

  2018-11-08

  

  Micro-array data has been submitted to Gene Expression Omnibus with GEO accession number: GSE72118. Competing financial interests Acknowledgements Introduction Recent studies in the stem cell field have demonstrated that cell fate transition could be achieved by introducing lineage-specifi

• The DNA fingerprint of Lymph AD iPS cell line was

  2018-11-08

  

  The DNA fingerprint of Lymph2-AD2-iPS cell line was identical to the parental lymphoblast line AD2-2 (Fig. 1D). Karyotype analysis was male (XY) and both lines exhibited a normal diploid chromosomal content (Fig. 1E). As depicted in the Dendrogram (Fig. 1F), the transcriptome of the parental lymphob

• miR a has been extensively studied

  2018-11-08

  

  miR-29a has been extensively studied in different fields. miR-29a has been reported to be associated with cardiac hypertrophy and fibrosis (Roncarati et al., 2014), and functions as a negative regulator of extracellular matrix remodeling (van Rooij et al., 2008). We have previously reported that miR

• In the current work we have attempted to address

  2018-11-08

  

  In the current work, we have attempted to address these issues. First, we have successfully generated of iPSCs from USCs, the Amyloid Beta-Peptide (1-40) Supplier that were derived from patients\' urine, using an integration-free reprogramming protocol. In this protocol, reprogramming factors OSKM

• Here we used iPSCs to

  2018-11-08

  

  Here, we used iPSCs to generate cardiomyocytes by reprogramming skin fibroblasts from two patients carrying dissimilar LQTS mutations. Associated with LQT2, HERG-A422T produces trafficking-defective HERG K+ azd2171 (Kv 11.1) that decrease the rapidly activating delayed rectifier current (IKr), whic

• br Results br Discussion hESCs demonstrate the potential to

  2018-11-08

  

  Results Discussion hESCs demonstrate the potential to serve as a starting cell population for bone regeneration, and previous studies report effective differentiation of hESCs to osteogenic lineage (Arpornmaeklong et al., 2010; Kärner et al., 2009). However, it remains important to better defi

• Since the discovery of these cells Ingram et al

  2018-11-08

  

  Since the discovery of these A 779 (Ingram et al., 2004), secondary colonies have been generated in several studies to assess the immaturity of ECFCs from blood or vascular wall and hierarchize them (Alphonse et al., 2015; Ingram et al., 2005; Patel et al., 2016). The aim of this work was to identi

• The following are the supplementary data related to

  2018-11-08

  

  The following are the supplementary data related to this article. Conflict of interest Introduction Mammalian eyes contain retinal stem cells (RSCs) that are capable of proliferating and differentiating into all of the cell types of the neural retina as well as the retinal pigmented epitheliu

• A recently developed gene editing technology using RNA guide

  2018-11-08

  

  A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

• br Results br Discussion As stem cells of

  2018-11-08

  

  Results Discussion As stem cyclohexamide of the skeleton, BM-MSC\'s lineage commitment, a crucial step thought to determine the yield of functional osteoblasts, needs to be tightly regulated. Yet how BM-MSC lineage commitment is regulated remains poorly understood. This study revealed that p38

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