• Numerous clinical trials phase II and phase III

  2019-05-08

  

  Numerous clinical trials (phase II and phase III) have been then designed to evaluate the efficacy of denosumab in oncology mainly in breast and prostate bone metastases (Table 1). These studies revealed that denosumab reduced significantly bone turnover markers similarly to osteoporotic patients. M

• According to the labeling of dabigatran in Japan

  2019-05-08

  

  According to the labeling of dabigatran in Japan, patients to be considered for the prescription of the lower dose of 220mg/day are as follows: (1) aged ≥70 years, (2) with moderate renal impairment (ClCr 30–50mL/min), (3) concomitant use of a p-glycoprotein inhibitor, and (4) history of hemorrhage

• In addition to inducing IKs dysfunction

  2019-05-08

  

  In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor

• Na segunda se o o texto analisa a emerg

  2019-05-08

  

  Na segunda seção, o texto analisa caspofungin emergência dos pentecostais e neopentecostais como atores políticos a partir do cenário da Assembleia Constituinte, responsável pela elaboração da Constituição brasileira de 1988. Por conseguinte, averiguamos a forma como este segmento religioso construi

• Cabe mencionar que en despu s de diez

  2019-05-08

  

  Cabe mencionar que, en 2005, después de diez años de trabajar en la Universidad de Pittsburgh, espacio de gran relevancia para la gestación de las antologías analizadas, Moraña se trasladó conotoxin Supplier la Universidad de Washington en St. Louis, donde, hasta la fecha, pasó a fungir como profeso

• First progress towards the targets should

  2019-05-08

  

  First, progress towards the 2020 targets should be measured through collation, presentation, and analysis of standardised core metrics that track country progress. Elimination and control targets in the WHO Roadmap could serve as initial standardised metrics. Efforts are being made to measure the pr

• A Framework Convention on Global Health FCGH

  2019-05-08

  

  A Framework Convention on Global Health (FCGH)—supported by civil society and global leaders—should become the centrepiece of this endeavour (). It would reform global governance for health to enhance accountability, transparency, and civil society participation and protect the right to health in tr

• Introduction Several types of cancers including those origin

  2019-05-08

  

  Introduction Several types of cancers, including those originating in the breast, prostate, and lung, have a propensity to metastasize to the bones [1,2]. Bone metastases severely impair skeletal metabolism, and result in important clinical sequelae, such as excruciating chronic bone pain and the s

• br Clinical material br Discussion TLI is regarded as

  2019-05-08

  

  Clinical material Discussion TLI is regarded as a well-tolerated, simple procedure with few acute or late clinical sequelae reported. However, pulmonary irradiation as a therapeutic modality for metastatic bone sarcomas is, although introduced 30 years ago, insufficiently evaluated to clearly

• We agree that this method is

  2019-05-07

  

  We agree that this method is an appropriate way to assess whether Buruli ulcer is over-represented in children, but this issue was not central to our study. We also felt that the introduction of external data, the quality of which we cannot assess and which might not be relevant to areas where Burul

• Funding US Centers for Disease Control and Prevention

  2019-05-07

  

  Funding US Centers for Disease Control and Prevention, US President\'s Malaria Initiative, Doris Duke Charitable Foundation, and Alpha Omega Alpha Honor Society. Declaration of interests Abstract Background Injuries are the cause of almost 6 million deaths every year, with 15–20% of these assoc

• br Inherited Arrhythmia Clinics br

  2019-05-07

  

  10. Inherited Arrhythmia Clinics The evaluation and treatment of Atractyloside Dipotassium Salt suspected of having inherited arrhythmias requires a multidisciplinary team and approach. The presentation is often that of a proband or family member who has experienced a life-threatening arrhythmi

• Since antithrombotic therapy for patients with AF

  2019-05-07

  

  Since antithrombotic therapy for patients with AF is rapidly changing with the increasing use of dabigatran, rivaroxaban, and apixaban, some of the primary issues that will influence the future revision of various guidelines (HRS [Heart Rhythm Society], ESC [European Society of Cardiology], ACC [Ame

• Since many decades bone tumours have stimulated imagination

  2019-05-07

  

  Since many decades, bone tumours have stimulated imagination of researchers and numerous therapeutic alternatives have been proposed [134,135, Fig. 4]. The better knowledge of OPG/RANK/RANKL system leads to the development of peptides mimicking OPG and blocking RANK–RANKL interactions [136–139]. Inh

• Numerous animal studies have demonstrated

  2019-05-07

  

  Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit

11567 records 733/772 page Previous Next First page 上5页 731732733734735 下5页 Last page