• br Introduction Concern has been raised over free estrogens

  2020-10-13

  

  Introduction Concern has been raised over free estrogens (estrone [E1], 17ß-estradiol [E2] and 17α-ethynylestradiol [EE2] particularly) in the past decade due to their endocrine disrupting effects on environmental biota [1], [2]. Estrogens are excreted by vertebrates primarily as sulfate or glucu

• Although both DNA DSBs and

  2020-10-13

  

  Although both DNA DSBs and DNA-PK activity increase with aging in skeletal muscle (Figure 1), we cannot conclude that aging-associated increase in DNA-PK activity is solely mediated by chromosomal breaks, as DNA-PK is also activated independently of chromosomal breaks by ROS (Li et al., 2014), which

• Interest in DGKs increased as it

  2020-10-13

  

  Interest in DGKs increased as it became clear that not only are they important for lipid homeostasis, they serve to modulate the relative levels of diacylglycerol (DAG) and phosphatidic Concanamycin A (PtdOH) that play critical roles in a variety of signaling pathways (Eichmann and Lass, 2015; Liu

• The combination of brequinar and

  2020-10-13

  

  The combination of brequinar and 5-fluorouracil (5-FU) has been evaluated to assess whether brequinar-induced uridine depletion would improve 5-FU activity. In cells, 5-FU is metabolized into FdUMP and inhibits thymidylate synthetase, which catalyzes the formation of thymidine monophosphate from deo

• br Experimental section br Author contributions br

  2020-10-13

  

  Experimental section Author contributions Acknowledgements Introduction Many Fmoc-Tyr(tBu)-OH in cells are sequential enzymatic reactions where the product of one enzyme serves as the substrate of a second enzyme (1, 2). Experimental evidence suggests that some of these consecutive enzym

• br Introduction Natural killer NK cells have an

  2020-10-13

  

  Introduction Natural killer (NK) cells have an unique ability to directly lyse transformed, virus-infected or stressed cells without prior sensitization or major histocompatibility complex (MHC) class I restriction [1], [2]. They were initially defined and shown to be important effectors of the i

• However recent studies revealed that the function of Crm

  2020-10-13

  

  However, recent studies revealed that the function of Crm1 might not only limit to nucleocytoplasmic transport, but also be involved in regulation of centrosome duplication. As the major microtubule organizing centers in animal cells, centrosomes play a significant role in cell cycle, spindle format

• Two major mechanisms including apoptosis and oxidative stres

  2020-10-12

  

  Two major mechanisms including apoptosis and oxidative stress have been suggested for MTX-induced cytotoxicity (Hafez et al., 2015; Neuman et al., 1999; El-Sheikh et al., 2015). It has been reported that MTX promotes cell death via apoptosis in both cancerous and non-transformed cells (Mazur et al.,

• These cognitive deficits may suggest

  2020-10-12

  

  These cognitive deficits may suggest that cognitive therapy and pharmacotherapy for gambling behavior may ultimately wish to consider genotyping as a means of better targeting treatment approaches. If core cognitive deficits are shown consistently in certain subgroups of gamblers based on genotype,

• The COMT gene maps to chromosome q Grossman et al

  2020-10-12

  

  The COMT gene maps to chromosome 22q11.2 (Grossman et al., 1992) and has two protein isoforms. The differences between S-COMT and longer MB-COMT are in the N-termini, which use alternative translation initiation sites and promoters. These two isoforms display different affinity and capacity for COMT

• br Introduction Al Awqati and his colleagues using R methyli

  2020-10-12

  

  Introduction Al Awqati and his colleagues using R(+)-methylindazone, R(+)-[(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)-oxy] acetic GS-9350 receptor (IAA-94) (Landry et al., 1987) isolated the first chloride intracellular ion channel (CLIC) proteins (p64) from bovine kid

• EP is the major receptor to mediate PGE

  2020-10-12

  

  EP4 is the major receptor to mediate PGE2-induced inflammatory pain. EP4 is upregulated by VX-809 in DRG neurons [16]. Intrathecal injection of the EP4 agonist produced pain responses [25]. Either systemic or local injection of EP4 antagonists relieves inflammatory pain [3], [16], [26]. However, th

• br Protein protein interactions of LEI L

  2020-10-12

  

  Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino 1632 substitution in the RSL can led to the inhibition of a totally different protease. We ha

• The chemical structures of I C MOI

  2020-10-12

  

  The chemical structures of I3C, 3MOI, and 3MI and the SR 2211 responsible for 3MI metabolism in rainbow trout and carp are shown in Fig. 4. Discussion To determine the individual CYP450 isoforms involved in 3MI metabolism, we used specific inhibitors for CYP1A, CYP3A and CYP2E1. Our results sug

• Concholepas concholepas our model species for

  2020-10-10

  

  Concholepas concholepas, our model species for this study, is a marine gastropod found along the Chilean coast that has become commercially important [25], [26], [27]. Until now, the main focus of immunology related to C. concholepas is the production of a novel hemocyanin that has been useful for t

11574 records 473/772 page Previous Next First page 上5页 471472473474475 下5页 Last page