• Cy5 NHS ester(Et): Technical Guidance for Biomolecule Labeli

  2026-07-09

  Cy5 NHS ester(Et) enables precise, water-soluble fluorescent labeling of amino groups in proteins and other biomolecules, supporting immunofluorescence, flow cytometry, and fluorescence microscopy. It is not recommended for ethanol-based workflows or long-term storage of labeling solutions, making it best suited for immediate-use, high-fidelity applications.

• Ibrexafungerp (SKU C8697): Reliable Antifungal Solutions in

  2026-07-08

  This article delivers evidence-based guidance for researchers and technicians using Ibrexafungerp (SKU C8697) in cell viability and antifungal susceptibility workflows. Drawing on robust in vitro and clinical data, it addresses practical questions on protocol optimization, data interpretation, and product reliability, highlighting how Ibrexafungerp’s unique properties ensure reproducible and sensitive results.

• PD 173074: Beyond Cancer—New Frontiers in FGFR1 Inhibition

  2026-07-08

  Explore the advanced roles of PD 173074 in dissecting FGFR1-driven pathways, from adipogenesis to angiogenesis. This in-depth review highlights unique mechanisms and experimental protocols, distinguishing PD 173074’s applications beyond conventional cancer research.

• Clasto-Lactacystin β-lactone: Precision Proteasome Inhibitor

  2026-07-07

  Clasto-Lactacystin β-lactone unlocks highly specific, irreversible proteasome inhibition for dissecting cellular protein degradation. Its potency, cell-permeability, and robust workflow compatibility empower advanced studies in cancer, neurodegeneration, and viral immunity research.

• Decoding Mitochondrial Dysfunction: TMRE’s Role in Translati

  2026-07-07

  Explore how Tetramethylrhodamine ethyl ester perchlorate (TMRE, SKU: C8197) empowers rigorous, mechanism-driven research on mitochondrial membrane potential and dysfunction. This article integrates pivotal mechanistic studies of ROS generation and apoptosis with strategic guidance for translational researchers, contextualizing TMRE’s application in advanced live-cell assays and future precision medicine.

• EZ Cap™ EPO mRNA (ψUTP): Stability and Neurorepair Benchmark

  2026-07-06

  EZ Cap™ EPO mRNA (ψUTP) is a high-purity, Cap 1-capped human erythropoietin mRNA engineered for robust translation and superior stability. The product leverages pseudouridine modification and enzymatic capping to enhance protein expression and minimize immune activation. This dossier details mechanistic, benchmarking, and workflow evidence supporting its use in neurorepair and erythropoiesis research.

• Moesin as a Diagnostic Biomarker of Endothelial Injury in Se

  2026-07-06

  The reference study identifies moesin (MSN) as a novel and quantifiable biomarker of endothelial injury in sepsis, demonstrating its correlation with disease severity and key inflammatory pathways. These findings highlight MSN’s potential for early diagnosis and severity assessment in clinical and experimental sepsis models.

• Rucaparib (AG-014699): Protocol Optimization in DNA Damage R

  2026-07-05

  Rucaparib (AG-014699) stands out in DNA damage response research, enabling precision radiosensitization and mechanistic insight in cancer models with DNA repair vulnerabilities. Discover best-practice workflows, troubleshooting tips, and the latest findings on apoptosis and transcriptional interplay to elevate your experimental outcomes.

• DRP1 Activation Drives Mitochondrial Fission and Glycolysis

  2026-07-04

  This study demonstrates that hyperoxia-induced DRP1 activation leads to mitochondrial fission and glycolytic reprogramming in alveolar type II (ATII) cells, contributing to the pathogenesis of bronchopulmonary dysplasia (BPD). The findings identify DRP1 as a potential therapeutic target and clarify the mechanistic links between mitochondrial dynamics and metabolic alterations in neonatal lung injury.

• Nitrocefin in β-Lactamase Assays: Protocols, Applications, a

  2026-07-03

  Nitrocefin, a gold-standard chromogenic cephalosporin substrate, enables rapid and precise colorimetric detection of β-lactamase activity, streamlining antibiotic resistance research and inhibitor screening. This article distills cutting-edge experimental workflows and troubleshooting strategies, translating recent pathogen research and advanced protocols into actionable guidance for modern microbiology labs.

• O-GlcNAcylation Links Wnt Signaling to Bone Formation via Gl

  2026-07-03

  This study reveals that Wnt3a-driven bone formation relies on dynamic O-GlcNAcylation, which rewires aerobic glycolysis in osteoblasts. The findings clarify how metabolic regulation via O-GlcNAcylation is essential for Wnt-induced osteogenesis, providing mechanistic insight into bone anabolism with potential implications for osteoporosis research.

• AZD3463 and the Next Chapter of Translational ALK/IGF1R Rese

  2026-07-02

  This thought-leadership article explores the mechanistic, experimental, and strategic dimensions of AZD3463—a dual ALK/IGF1R inhibitor—within the context of translational neuroblastoma research. It provides actionable guidance for targeting the PI3K/AKT/mTOR axis, overcoming resistance, and optimizing combination therapies, while situating AZD3463's unique value proposition in the evolving landscape of pathway-targeted oncology.

• Cy5 Goat Anti-Rabbit IgG (H+L) Antibody: Signal Amplificatio

  2026-07-02

  Explore how the Cy5 Goat Anti-Rabbit IgG (H+L) Antibody advances fluorescence-based detection in antiviral immunity research. This article uniquely bridges molecular immunology and practical assay optimization, offering deep insight into assay sensitivity and protocol design.

• Nascent Cone Precursors as the Origin of Human Retinoblastom

  2026-07-01

  This study establishes, using RB1-deficient retinal organoids, that ATOH7+/RXRγ+ nascent cone precursors are the earliest and primary cellular origin of human retinoblastoma. These findings provide new mechanistic insights into tumor initiation and offer refined targets for future therapeutic strategies in ocular oncology.

• DeferoxamineB: Strategic Iron Chelation in Translational Onc

  2026-07-01

  This article explores how Deferoxamine (DeferoxamineB) advances cancer research by modulating ferroptosis and cuproptosis, integrating mechanistic insights with practical guidance for translational scientists. Drawing from state-of-the-art metabolic intervention studies, we position DeferoxamineB as a pivotal tool for designing next-generation assays and therapeutic strategies that target iron metabolism, regulated cell death, and tumor immunity.

11881 records 2/793 page Previous Next 12345 下5页 Last page